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Despair from a spiritual definition is where a consciousness chooses its self into a corner where no matter what decision is made, the end result is non-movement in the soul's evolution.
It is important to stop the negative thoughts through meditation or another physical/soulful process. There are no standard processes as each of you are unique representations of your soul.
Look despair in the face & consciously decide to make different choices. It will not be easy. Many linear (inappropriate) things will fall away. The goal is to jump start the soul energy. By doing so, a new creative opportunity will become available.